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KMID : 0387720140250020152
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Korean Journal of Blood Transfusion
2014 Volume.25 No. 2 p.152 ~ p.159
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Membranous Nephropathy Concurrent with Interstitial Nephritis after Allogenic Hematopoietic Stem Cell Transplantation in a Patient with Acute Lymphoblastic Leukemia
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이현우:Lee Hyun-Woo
강수훈:Kang Soo-Hoon/박가은:Park Ga-Eun/이경호:Lee Kyung-Ho/홍연수:Hong Yun-Soo/권기영:Kwon Gee-Young/정철원:Jung Chul-Won/이정은:Lee Jung-Eun
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Abstract
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Kidney is rarely an involved organ of graft-versus-host disease (GVHD). Here, we report on a case of membranous nephropathy and interstitial nephritis after allogenic hematopoietic stem cell transplantation (HSCT) in a 44-year-old female patient with acute lymphoblastic leukemia. The patient received GVHD prophylaxis with low dose steroid, cyclosporin, and short course methotrexate. Cyclosporine was tapered out 17 months after allogeneic HSCT. Thereafter, the patient developed kidney impairment and nephrotic range proteinuria. Kidney biopsy revealed membranous nephropathy concurrent with interstitial nephritis.
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KEYWORD
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Membranous nephropathy, Allogenic hematopoietic stem cell transplantation, Graft-versus-host disease, Interstitial nephritis
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